Conjugated dienes

Abstract

NEW MATERIAL:A conjugated diene shown by formula I (R 1 is group shown by formula II to formula IV or formyl; R 2 is CN, formyl or CO 2 R 6 ; R 3 to R 6 are 1-4C alkyl and further R 3 and R 4 are bonded to form ring). EXAMPLE: A compound shown by formula V. USE: An intermediate capable of industrially and advantageously producing sarcophytol A having anti-carcinogenic promoter action and antitumor action from an inexpensively and readily obtainable raw material without passing through an oxidation process of terminal methyl group. PREPARATION: A compound shown by formula VII which is obtained from a compound shown by formula IV through Wittig type reaction process or further reduction process, epoxidizing process and isomerizing process is allowed to react with a compound shown by formula VIII to give a compound shown by formula I (R 1 is the group shown by formula II), which is reduced or reduced and then oxidized to give a compound shown by formula I (R 1 is the group shown by formula III). Then this compound is oxidized to give a compound shown by formula I (R 1 =CHO), which is subjected to Wittig type reaction to give a compound shown by formula I (R 1 is the group shown by formula IV). COPYRIGHT: (C)1991,JPO&Japio

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    US-7235688-B1June 26, 2007University Of Notre Dame Du LacProcess for preparing histone deacetylase inhibitors and intermediates thereof